Kcng4

View mouse Kcng4 Chr with phenotypes, sequences, polymorphisms, proteins, references, function, expression.

Kcng4. Potassium voltagegated channel modifier subfamily G member 4 (Kcng4) antibody I01Rik antibody AW antibody KV63 antibody KV64 antibody sidkey246g233 antibody Protein level used designations for Kcng4. Potassium voltagegated channel subfamily G member 4 is a protein that in humans is encoded by the KCNG4 gene The protein encoded by this gene is a voltagegated potassium channel subunit References ^ a b c GRCh38 Ensembl release ENSG Ensembl, May 17. Kcng4 summary tissue cell type pathology brain blood cell tissue atlas tissues adipose tissue adrenal gland amygdala appendix bcells basal ganglia bone marrow breast cerebellum cerebral cortex cervix, uterine colon corpus callosum dendritic cells ductus deferens duodenum.

Expression of KCNG4 (Kv64) in cancer tissue The cancer tissue page shows antibody staining of the protein in different cancers. An interesting study was recently conducted on women who were in labor and the results showed that one percent of them had a rare genetic variant called KCNG4 which raised their pain threshold to astonishing levels and acted like a “natural epidural”. KCNG4 provides the code for the production of a protein that forms part of a 'gate', controlling the electric signal that flows along our nerve cells As the joint first author Dr Van Lu showed.

Symbol Kcng4 tm11(KOMP)Vlcg Name potassium voltagegated channel, subfamily G, member 4;. Paired RGC Recording Paradigm in the Kcng4cre;Thy1stopYFP Line 1 Mouse In initial experiments, our study focused on the ON αRGCs in the mouse retina, which are coupled indirectly via GJs made with two or more subtypes of PACs (25 ⇓ –27)We used the Kcng4cre;Thy1stopYFP line 1 (Kcng4YFP) mouse line in which the ON and OFF αRGC subtypes uniquely express yellow fluorescent protein. The rare gene variant, called KCNG4, is believed to inhibit how pain is processed by the nervous system and acts as a 'natural epidural' Researchers from the University of Cambridge found that it.

See Taconic Bioscience’s Constitutive Knock Out mouse, model # Kcng4 We use cookies to improve your browsing experience, gather website statistics, and provide more personalized services, both on this website and through other media. Kcng4 summary tissue cell type pathology brain blood cell tissue atlas tissues adipose tissue adrenal gland amygdala appendix bcells basal ganglia bone marrow breast cerebellum cerebral cortex cervix, uterine colon corpus callosum dendritic cells ductus deferens duodenum. Targeted mutation 11, Velocigene MGI ID MGI Gene Kcng4.

Prof Geoff Woods and a team from the Cambridge Institute for Medical Research studied a group of 196 women who didn’t request or require analgesia during their first labour, finding “a significant overrepresentation” of a rare, but by no means oneoff, variation in the gene KCNG4. Kcng4 tm2a(EUCOMM)Wtsi KO first allele (reportertagged insertion with conditional potential) Targeting vectors, ES Cells The IMPC Newsletter Get highlights of the most important data releases, news and events, delivered straight to your email inbox Subscribe to newsletter. Expression of KCNG4 (Kv64) in cancer tissue The cancer tissue page shows antibody staining of the protein in different cancers.

Popping out of the sequencing results was an overrepresented single nucleotide polymorphism (SNP) in the gene KCNG4, which encodes the voltagegated potassium channel subunit Kv64, in four patients In this case, the SNP causes a heterozygous missense mutation in KCNG4;. One Sentence Summary Human labor pain is influenced by KCNG4 /KV64 ion channel, which modulates the excitability of sensory neurons Thirtythree of these 196 women underwent comprehensive sensory and psychometric tests, which revealed higher experimental pain thresholds, particularly to deep somatic pressure, when compared to matched controls. Popping out of the sequencing results was an overrepresented single nucleotide polymorphism (SNP) in the gene KCNG4, which encodes the voltagegated potassium channel subunit Kv64, in four patients In this case, the SNP causes a heterozygous missense mutation in KCNG4;.

Meanwhile, Professor Geoff Woods, from the Cambridge Institute for Medical Research, found those in the test group had a higherthanexpected prevalence of the rare gene, named KCNG4 Advert Only one per cent of the female population actually have the genetic variant, which controls the electric signals in our nerve cells. KCNG4 51 diseases associated Potassium channel subunit that does not form functional channels by itself Can form functional heterotetrameric channels with KCNB1;. Alternative Name KCNG4 (Kcng4 Antibody Abstract)Background Description Potassium channel subunit that does not form functional channels by itself Can form functional heterotetrameric channels with KCNB1, modulates the delayed rectifier voltagegated potassium channel activation and deactivation rates of KCNB1 (PubMed).

Potassium voltagegated channel subfamily G member 4 is a protein that in humans is encoded by the KCNG4 gene The protein encoded by this gene is a voltagegated potassium channel subunit. Expression of KCNG4 (Kv64) in cancer tissue The cancer tissue page shows antibody staining of the protein in different cancers. Using pysradb Obtaining SRA metadata $ pysradb metadata SRP head study_accession experiment_accession experiment_title experiment_desc organism_taxid organism_name library_strategy library_source library_selection sample_accession sample_title instrument total_spots total_size run_accession run_total_spots run_total_bases SRP SRX Reference Epigenome ChIPSeq Analysis of.

How does KCNG4 regulate pain sensations?. KCNG4 provides the code for the production of a protein that forms part of a ‘gate’, controlling the electric signal that flows along our nerve cells As the joint first author Dr Van Lu showed, sensitivity of this gatekeeper to electric signals that had the ability to open the gate and turn nerves on was reduced by the rare variant. Modulates the delayed rectifier voltagegated potassium channel activation and deactivation rates of KCNB1;.

Entrez Gene Summary for KCNG4 Gene Voltagegated potassium (Kv) channels represent the most complex class of voltagegated ion channels from both functional and structural standpoints. KCNG4 inhibits the ability of nerve cells to send pain signals to the brain, where the sensation of pain is then registered This means that women who carry the gene should have a higher pain. KCNG4 is a member of the potassium channel, voltagegated, subfamily G This member functions as a modulatory subunit The protein has strong expression in brainVoltagegated potassium (Kv) channels represent the most complex class of voltagegated ion channels from both functional and structural standpoints.

Modulates the delayed rectifier voltagegated potassium channel activation and deactivation rates of KCNB1 (PubMed) approved symbol KCNG4 Target Match from ortholog Match from drug Match from phenotype. Potassium channel subunit that does not form functional channels by itself Can form functional heterotetrameric channels with KCNB1;. Invitrogen AntiKCNG4 Polyclonal, Catalog # PA5253 Tested in Western Blot (WB) and Immunohistochemistry (Paraffin) (IHC (P)) applications This antibody reacts with Human, Mouse samples Supplied as 100 µL purified antibody (158 mg/mL).

Expression of KCNG4 (Kv64) in cancer tissue The cancer tissue page shows antibody staining of the protein in different cancers. The Genetic Testing Registry (GTR) provides a central location for voluntary submission of genetic test information by providers The scope includes the test's purpose, methodology, validity, evidence of the test's usefulness, and laboratory contacts and credentials The overarching goal of the GTR is to advance the public health and research into the genetic basis of health and disease. ), KCNG4 altered the typical Kv21 channel propertiesKCNG4 accelerated the time course of activation, hyperpolarized the threshold for activation, and.

The gene view histogram is a graphical view of mutations across KCNG4 These mutations are displayed at the amino acid level across the full length of the gene by default Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left. Whole cell extract (30 μg) was separated by 10% SDSPAGE, and the membrane was blotted with KCNG4 antibody (GTX) diluted at The HRPconjugated antirabbit IgG antibody (GTX) was used to detect the primary antibody. The wild type (normal) variant of the KCNG4 gene leads to the production of a protein subunit K V 64 This protein, when coupled with another protein called subunit K V 21, forms a channel through which pain signals are conducted to the brain In the rare variant form of KCNG4, there is change in the amino acid, leading to a slightly different.

With this particular SNP, a valine amino acid is changed to a methionine. How does KCNG4 regulate pain sensations?. The wild type (normal) variant of the KCNG4 gene leads to the production of a protein subunit K V 64 This protein, when coupled with another protein called subunit K V 21, forms a channel through which pain signals are conducted to the brain In the rare variant form of KCNG4, there is change in the amino acid, leading to a slightly different.

Potassium voltagegated channel subfamily G member 4 is a protein that in humans is encoded by the KCNG4 gene The protein encoded by this gene is a voltagegated potassium channel subunit References ^ a b c GRCh38 Ensembl release ENSG Ensembl, May 17. With this particular SNP, a valine amino acid is changed to a methionine. Protocol Standard PCR Assay Kcng4 Version 1 0 Get PDF Notes The genotyping protocol(s) presented here have been optimized for reagents and conditions used by The Jackson Laboratory (JAX).

HEK293T cell overexpressing KCNG4 Breadcrumb Home / Idg hek293t kcng4 v5 oe / Cell ID IDGHEK293TKCNG4V5OE RRID CVCL_YA61 Gene KCNG4 Cell Type Stable overexpression cell line Parent Cell Line HEK293 Request email email protected ORF sequence. KCNG4 Potassium voltagegated channel subfamily G member 4;. KCNG4 potassium voltagegated channel modifier subfamily G member 4 (human) Gene ID , updated on 24Sep Summary Voltagegated potassium (Kv) channels represent the most complex class of voltagegated ion channels from both functional and structural standpoints Their diverse functions include regulating neurotransmitter release.

Modulates the delayed rectifier voltagegated potassium channel activation and deactivation rates of KCNB1 (PubMed) approved symbol KCNG4 Target Match from ortholog Match from drug Match from phenotype. This rare gene variant, called KCNG4, is believed to inhibit how pain is processed by the nervous system Svante Pääb, coauthor of the latest study, said 'Whether Neanderthals experienced more. Paired RGC Recording Paradigm in the Kcng4cre;Thy1stopYFP Line 1 Mouse In initial experiments, our study focused on the ON αRGCs in the mouse retina, which are coupled indirectly via GJs made with two or more subtypes of PACs (25 ⇓ –27)We used the Kcng4cre;Thy1stopYFP line 1 (Kcng4YFP) mouse line in which the ON and OFF αRGC subtypes uniquely express yellow fluorescent protein.

AntiKCNG4 antibody produced in rabbit is polyclonal, unconjugated and is suitable for immunohistochemistry, western blot. NCBI Description of KCNG4 Voltagegated potassium (Kv) channels represent the most complex class of voltagegated ion channels from both functional and structural standpoints Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle. WB analysis of human B lymphoblast cells using GTX KCNG4 antibody at 021μg/ml REFERENCE There are currently no references for KCNG4 antibody, Nterm (GTX) Be the first to share your publications with this product Submit a Reference REVIEW.

KCNG4 potassium voltagegated channel modifier subfamily G member 4 Overview;. Potassium voltagegated channel modifier subfamily G member 4 (Kcng4) antibody I01Rik antibody AW antibody KV63 antibody KV64 antibody sidkey246g233 antibody Protein level used designations for Kcng4. KCNG3 and KCNG4 gene expression is significantly downregulated in HSCR colon, suggesting a role for these genes in colonic motility KCNG3 and KCNG4 downregulation within ganglionic specimens highlights the physiologically abnormal nature of this segment in HSCR patients.

Ottschytsch et al (02) found no evidence that KCNG4 could coassemble in yeast 2hybrid assays, and they found no potassium currents when KCNG4 was expressed alone in mouse fibroblasts However, when coexpressed with Kv21 (KCNB1;. Belongs to the potassium channel family. KCNG4_MOUSE Accession i Q80XM3 Primary (citable) accession number Q80XM3 Entry history i Integrated into UniProtKB/SwissProt February 26, 08 Last sequence update June 1, 03 Last modified December 2, This is version 133 of the entry and version 1 of the sequence.

KCNG4 51 diseases associated Potassium channel subunit that does not form functional channels by itself Can form functional heterotetrameric channels with KCNB1;. KCNG4_HUMAN Accession i Q8TDN1 Primary (citable) accession number Q8TDN1 Secondary accession number(s) Q96H24 Entry history i Integrated into UniProtKB/SwissProt November 28, 02 Last sequence update June 1, 02 Last modified December 2, This is version 168 of the. KCNG4_MOUSE Accession i Q80XM3 Primary (citable) accession number Q80XM3 Entry history i Integrated into UniProtKB/SwissProt February 26, 08 Last sequence update June 1, 03 Last modified December 2, This is version 133 of the entry and version 1 of the sequence.

Potassium voltagegated channel subfamily G member 4 is a protein that in humans is encoded by the KCNG4 gene The protein encoded by this gene is a voltagegated potassium channel subunit. United States Biological's Pab Rb x human KCNG4 antibody is a Rabbit Polyclonal antibody This antibody has been shown to work in applications such as ELISA, Immunohistochemistry, and Western Blot The Pab Rb x human KCNG4 antibody was generated using potassium voltagegated channel modifier subfamily G member 4 as the antigen and it reacts with Human, and Mouse. KCNG4 inhibits the ability of nerve cells to send pain signals to the brain, where the sensation of pain is then registered This means that women who carry the gene should have a higher pain.

Kcng4 tm2a(EUCOMM)Wtsi KO first allele (reportertagged insertion with conditional potential) Targeting vectors, ES Cells The IMPC Newsletter Get highlights of the most important data releases, news and events, delivered straight to your email inbox Subscribe to newsletter. Meanwhile, Professor Geoff Woods, from the Cambridge Institute for Medical Research, found those in the test group had a higherthanexpected prevalence of the rare gene, named KCNG4 Advert Only one per cent of the female population actually have the genetic variant, which controls the electric signals in our nerve cells. Examination of Kcng4YFP retinal crosssections, in which the three αRGC subtypes can be distinguished by dendritic lamination, indicated that all three subtypes survived (Figure 1B) As a consequence, αRGCs and M1RGCs, which comprise ∼6% and ∼3% of all RGCs in the normal retina, respectively, accounted for 23% and 11% of surviving RGCs.

KCNG4_HUMAN Accession i Q8TDN1 Primary (citable) accession number Q8TDN1 Secondary accession number(s) Q96H24 Entry history i Integrated into UniProtKB/SwissProt November 28, 02 Last sequence update June 1, 02 Last modified December 2, This is version 168 of the. This rare gene variant, called KCNG4, is believed to inhibit how pain is processed by the nervous system Svante Pääb, coauthor of the latest study, said 'Whether Neanderthals experienced more. Prof Geoff Woods and a team from the Cambridge Institute for Medical Research studied a group of 196 women who didn’t request or require analgesia during their first labour, finding “a significant overrepresentation” of a rare, but by no means oneoff, variation in the gene KCNG4.

KCNG4 potassium voltagegated channel modifier subfamily G member 4 Voltagegated potassium (Kv) channels represent the most complex class of voltagegated ion channels from both functional and structural standpoints Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability.